Basic pharmaceutical Principles of Ayurvedic Formulations : 

Dr. Madhuri Pawar 

Associate Professor, BVDUCOA, Pune 

Content : 

Principles for  selection of raw materials[ Herbs, Mineral-metals, animal products]

Principles for manufacture of ayurvedic medicines 

Ayurvedic pharmaceutics deals with preparation of herbal and herbomineral formulations by applying specific guidelines and principles enumerated in classical texts.

 In current scenario different modern techniques applied for selection of raw drugs  and manufacture of medicines are to be taken in consideration. 

In laboratories , Small scale units and also in large scale pharmacy units it is mandatory to follow  authentic published Ayush  guidelines.

Cumulatively it is helpful to prepare quality formulations which produces desired effects claimed in ayurvedic classical texts.

  Hair Care : Transformation of  potent group of Herbal drugs in Gel form 

Dr. Madhuri Pawar, Dr. Nilima Dharkar 

Ayurvedic literature reveals that avoidance of oil application and improper cleaning of scalp, sleeping in day time, night vigil, exposure to dust, hot weather are the causative factors for development of dandruff.

As per ayurvedic perspective, due to vitiation in Vata and Kapha entities, dryness occurs  and specific symptoms are predominantly seen at that region. These specific symptoms can be  correlated with dandruff.

Due to imbalanced diet, environmental pollutants and improper hair care, individual’s scalp may get affected. Dandruff is a scalp disorder which is characterized by excessive shedding of skin cells, itchy-flaky skin and invisible inflammation. Human beings are more prone for occurrence of dandruff at puberty to middle age.

Moreover it is stated that approximately 50% adult population is affected by dandruff worldwide while the 18.38% Indian community is affected by this disorder.

To combat with occurrence of dandruff and associated symptoms, various anti dandruff agents having chemical entities in the form of shampoos, gels, creams etc are utilized in existing current practice.

Though these agents have therapeutic potential to treat dandruff like disorders but might be having risk to produce untoward effects to human scalp and hair.

Thus specific herbal drugs mentioned in ayurvedic literature having anti itching, antifungal and anti-inflammatory actions are helpful to treat such conditions and useful to get rid from dandruff . 

These herbs can be converted into different current, easy applied cosmetic forms , especially in gel forms for management of dandruff which are considerably safe and effective . Additionally, it might be helpful to reduce hair fall and maintain healthy status of scalp and hair.

Herbs: Raktachandan, Neem,  Daruharidra, Sarshap,  Karanj, Aragvadha, Musta etc 

Different potent parts of  these herbal drugs --can be used in single or in combinations, can be modified with new innovation methods of preparations. These new developed forms [ Shampoos, oils, gels] of herbs might be effective and may show higher shelf life. 

ve

dandruff.

A Book Review : Ayurvedic Nutrition and cooking

Ayurvedic Nutrition and Cooking : Book Review

 Living a Healthy Life with a healthy food is the concept elaborated easier written by author, Dr. Sunanda Ranade

The book is a great source of healthy recipes for both beginners and experienced persons who are much more affectionate towards Ayurved. Book is featuring delicious, easy to make recipes by simple complete explanation with beautiful photos. This is possibly the best recipe book one can read.

The traditional ayurvedic diet is purely put in a modernized version of the foods that our ancestors ate, hence the name “Ayurvedic nutrition and cooking”.  Ayurvedic nutritional diets are made up of nutrient-rich organic foods, includes different types of cereals, grains, natural oils, fats, nuts, fruits and additive herbal drugs. The food articles mentioned are prepared by application of basic principles of ayurvedic traditional science.

Great efforts are taken by author to describe fundamental concepts of body-mind constitutions, assessment of individual’s physical and psychological characteristics. The attempt is made by author to address importance of daily food items for specific constitution in purview of prevention and management of illness.

Especially in basic principles of nutrition chapter explanation about wholesome and unwholesome dietary products, accountability of eight factors in dietetics, quality properties and pharmacological actions of food substances are well narrated. Outstanding recipes from the book include milk processed with herbal drugs, Indian specific snacks and rice recipe, leafy-non leafy vegetables-curries processed with spices and coconuts, variety of mouth -watering pickles. All these food articles are often served as snacks, main course foods and some are the taste enhancers.

The book does offer advice about the benefits of these food stuffs in relation to ayurvedic Vata-Pitta and Kapha entities along with the desired effects on constituents of human being. This book will play an important role to globalize the concept of ayurvedic cooking.

                                                                       

                                                                                    Dr. Madhuri Pawar, Associate Professor

                                                            Dept of Ayurvedic pharmaceutics and pharmacology

                                                            BV[Deemed to be University] College of Ayurved, Pune

Research Article Published in e journal of Ayurved --reference for PG student

 

                                                                                                            Rasamruta, 12:16, August 2020

Preparation and toxicity study of Kukkutand Twak [Hen Egg Shell] Bhasma treated

[Bhavana] with different herbal juices

Dr. Madhuri Pawar*

Bharati Vidyapeeth [Deemed to be University], college of Ayurved , Pune

Abstract

Introduction: Kukkutand twak bhasma is the ayurvedic medicine advised to treat calcium

deficiency and leucorrhea like disease conditions. In preparation of KTB variations are found in

usage of herbal drugs and pattern of temperature for incineration.

Objectives: Thus the attempt was made to formulate KTB samples with different herbal

combinations and temperature ranges on Kukkutand twak [KT]. Physico- chemical analysis and

safety data of KTB is generated.

Material and methodology: Purified KT was processed in Kumari Swaras and incinerated in

Gajaputa to prepare four samples of KTB. While KT was triturated with Kumari Swaras, Nimbu

Swaras and Gulab Jala, processed in Laghu Puta to prepare three samples of KTB. Analysis of

KTB samples was done in laboratory. One sample of KTB was tested for toxicity through acute

and subacute studies.

Results and conclusion: KTB prepared in seven and three Gajaputa revealed white colour but

little bit burning sensation. KTB-M-7GP showed high percentage of calcium than other KTB-GP

samples. KT incinerated in three cycles of Laghuputa showed grayish colour with no burning

sensation and estimated quantitative concentration of calcium. In acute toxicity study, animals

didn’t show any mortality and morbidity. In subacute study, sample of KTB didn’t show any

abnormal change in ileum and bone; insignificant inflammatory lesions are observed in liver and

kidney. Present study has demonstrated different preparation methods and analytical data for

KTB samples processed in Gajaputa and Laghu puta. Acute and subacute toxicity study records

have been illustrated for KTB sample processed with Kumari Swaras in Gajaputa.

Two formulations of Guduchi : Preparation and Organoleptic tests

Dr.Vaidehi Patankar, Dr. Madhuri Pawar, Dr Swati Gadgil

Guduchi is one of the “Medhya Rasayan” drug stated in Charak Samhita with its specific form of administration i.e. “Swaras” [Fresh juice].

Many previous research works are there with different forms of Guduchi such as Guduchi Choorna , Kwath or ethanolic and water extractives in which Guduchi Kanda (stem) is used.

Here we have used Fresh Guduchi Kanda (Stem), Patra (Leaves) and Moola(Roots)  

Identification and Authentication of Raw Drug

Whole plant of Guduchi (Tinospora Cordifolia) was used as a Raw Drug.

It was handpicked sample and identified from botany expert from IRSHA, Pune.

Authentication with Macroscopic and Microscopic characters of raw drug was done in IDRAL Laboratory, Pune,

Pharmaceutics of Guduchi Swaras

In present study Guduchi Swaras was prepared as per the standard protocol stated in Sharangdhar Samhita Madhyam Khanda 1^st Chapter verse no.2.

आहतात् तत्क्षणाकृष्टात् द्रव्यात् क्षुण्णात् समुद्धरेत् I

वस्त्र निष्पिडितो यः सः रसः स्वरसः उच्यते II

1. Manufacturing of Guduchi Swaras

2. Analysis of Guduchi Swaras

Method:

Identified and Authenticated Guduchi Whole plant was handpicked from authentic source.

Guduchi Stem having bitter taste was selected for study.Heart shaped green leaf and fresh roots were collected from same plant source.

Preparation of Guduchi swaras:

Standard Operating Procedures were carried out throughout the process.

Ingredients of Gududhci Swaras :’

Sr.No .	Material Used	Part Used	Quantity
1.	Guduchi (Tinospora cordifolia)	Whole plant (Total)	5000gms
1.1	Guduchi stem	Kanda	3500 gms
1.2	Guduchi leaves	Patra	1000 gms
1.3	Guduchi roots	Moola	500 gms
2.	Water	-	1200mL

Instruments:

Mortar-Pestle, Wet Grinder, Measuring cylinder, Iron Vessel, Spoon, Muslin Cloth, Gas Stove

Procedure:

·         Cleaning: Whole plant of Guduchi were separated as Stem, Roots and Leaves and weighed individually. An Individual collected part of plants were washed under running tap water for 3 times.

·         Grinding: The washed stem, small roots and leaves were cut into small pieces and pounded over stony mortar-Pestle. The pounded mixture was put into wet grinder with 25% of water to have moderate rough paste.

·         Filtering:

Obtained rough paste was taken into a clean muslin cloth and tied tightly and it was squeezed to have Guduchi Swaras. It was then measured with measuring cylinder.

·         In process and final testing was done as per the ayurvedic parameters further Guduchi Swaras was analyzed with API parameters.

      Preparation of Guduchi Kalpa:

For better palatability and to increase shelf life of Guduchi swaras “Kalpa” was formulated. It was prepared as per the standard protocol stated for avaleha in  Sharangdhar Samhita Madhyam Khanda 8th chapter verse No.1 as “ Kalpa is to be consider as an advance form of “Avaleha Form”

क्वाथादिनां पुनः पाकाद्घनत्वं सा रसक्रिया I

सोsवलेहश्च लेहः स्यात् तस्य मात्रा पलोन्मिता II 

Table for Quantity of Raw drug 

Sr.No	Raw Drug used	Quantity	Time required to manufacture
1.	Guduchi swaras	350mL	45 Min
2.	Sita (Sugar)	700 gms

ORGNAOLEPTIC CHARACTERISTICS OF GUDUCHI SWARAS

ORGANOLEPTIC TEST
Sr.No.	Parameters	Observations
1.	Shabda	-
2.	Sparsha	Picchila
3.	Roopa	Dark Green colour
4.	Rasa	Tikta
5.	Gandha	Ugra Gandhi

ORGNAOLEPTIC CHARACTERISTICS OF GUDUCHI KALPA

ORGANOLEPTIC TEST
Sr.No.	Parameters	Observations
1.	Shabda	Not applicable
2.	Sparsha	Khar-Sushka
3.	Roopa	Cream  colour
4.	Rasa	Madhur-Tikta
5.	Gandha	Sugandhi

Interpretation:

Handpicked sample of Fresh Guduchi [Tinospora cordifolia] identified and authenticated

Two dosage forms of Guduchi prepared as per standard ayurvedic protocols

Standard operating procedures for Guduchi Swaras and Kalpa are developed.

Organoleptic characteristics of both formulations are estimated